| has gloss | eng: Exome sequencing (also known as targeted exome capture) is an efficient strategy to selectively sequence the coding regions of the human genome to identify novel genes associated with rare and common disorders . Routine whole genome sequencing of large numbers of individuals is still not feasible partly due to the high cost associated with the technique. At present, it is necessary to use an alternative approach, in which certain regions of the genome, such as the “exome”, are targeted, enriched and sequenced, which requires ~5% as much sequencing as a whole genome . It is estimated that the protein coding regions of the human genome constitute about 85% of the disease-causing mutations . |
